My top recommendation is to understand your job industry.
Are you in a very corporate job function or a more flexible and creative one? You know the type of corporate job to consider, right? Accountant, lawyer, banker, HR manager, etc. These professions will have a typical corporate culture, so the resumes in those industries are expected to be very clean and concise. Layout wise this will mean that the resume should be a one-pager (two at most), color-limited, and simply designed. Creative professions like designers, project managers, video editors, marketing and sales managers will have a lot more leeway. Wild colors, varying fonts, and cool artwork are all fair game. For those professional industry jobs previously mentioned, these things should be left out or at least kept at a minimum. Black, dark blue and white are about the only colors that should be shown. A clean font, like Arial or Times New Roman should be used to keep things standard and easy to read. Lastly, there should be no distracting design or artwork embedded into the resume unless it is very simple.